4-D PLUS KIT

Overview

4-D PLUS KIT is a Schedule H antibiotic.

4-D PLUS KIT is composed of: ETHAMBUTOL HYDROCHLORIDE (1100 MG), PYRAZINAMIDE (800 MG), RIFAMPICIN (600 MG), ISONIAZID (300 MG)

Ethambutol is an antibiotic that prevents growth of the tuberculous bacteria in the body.It stops the growth of TB cells. Ethambutol is used with other medications to treat tuberculosis.This antibiotic treats only bacterial infections. It will not work for viral infections. Using any antibiotic when it is not needed can cause it to not work for future infections.

Pyrazinamide is an antibiotic that fights bacteria. Pyrazinamide is used to treat tuberculosis (TB) in adults and children. Pyrazinamide must be used with other TB medicines. Tuberculosis can become resistant to treatment if pyrazinamide is used alone.

Rifampicin is an antibiotic. It works by inactivating a bacterial enzyme (RNA-polymerase) which is required by bacteria to make essential proteins and to reproduce. Rifampicin is used in the treatment of tuberculosis and leprosy.
Isoniazid is an antibiotic that fights bacteria. Isoniazid is used to treat and to prevent tuberculosis (TB). You may need to take other TB medicines in combination with isoniazid. When treating active TB, isoniazid must be used with other TB medicines. Tuberculosis can become resistant to treatment if isoniazid is used alone.

Usage

ETHAMBUTOL HYDROCHLORIDE is generally used to treat: Tuberculosis
ETHAMBUTOL HYDROCHLORIDE can address symptoms like: Chest Pain, Weight Loss (unintentional), Night Sweats, Fever, Bloody Or Red Colored Vomit, Loss Of Appetite, Shortness Of Breath

PYRAZINAMIDE is generally used to treat: Tuberculosis

RIFAMPICIN is generally used to treat: Tuberculosis, Leprosy

ISONIAZID is generally used to treat: Tuberculosis

Frequently Asked Questions

Q: Is it safe on my liver?
A: Not Safe

Q: Is it safe on my kidney?
A: Not Safe

Q: Can I take it with alcohol?
A: Not Safe

Q: Is it safe for children?
A: Not Advised for age < 12yrs

Q: Can it be taken during pregnancy?
A: Not enough studies to prove Risk – Ask your Doctor

Q: Is it safe to take for someone breastfeeding?
A: Not Safe

How Do I Take It?

4-D PLUS KIT is generally taken Before Food.

Precautions for 4-D PLUS KIT and its Constituents


  • You should not use ethambutol if you are allergic to it.
  • You may not be able to take ethambutol if you cannot recognize or report any changes in your vision.
  • Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.
  • Do not take ethambutol in larger or smaller amounts or for longer than recommended.
  • Tell your doctor if you have ever used tuberculosis medicine before. Your dose may be different if you have been treated for tuberculosis in the past.
  • Ethambutol may be taken with food if it upsets your stomach.
  • Your blood cells, kidney function, and liver function may also need to be checked.
  • Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.
  • Do not take extra medicine to make up the missed dose.
  • Avoid taking an antacid containing aluminum hydroxide within 4 hours after you take ethambutol.
  • It may cause dizziness, do not drive a car or operate machinery while taking this medication. Avoid long-term use of this medication.
  • Ethambutol may cause live bacterial vaccines to not work as well. Do not have any immunizations/vaccinations while using this medication.

Caution should be exercised in patients with history of liver or kidney disease, diabetes, gout, high uric acid level in the blood, alcoholism, who are taking other medications, during pregnancy and breastfeeding. Avoid alcohol consumption while taking this medication. Avoid live vaccination during treatment period.

It is best taken on an empty stomach. If you get an upset stomach, try taking it with small portions of food. Your urine, tears and other secretions may become orange-red in colour. Avoid using contact lenses since they may become discolored. Avoid taking hormone-based birth control methods as Rifampicin may decrease their effectiveness.
Caution should be exercised in patients with history of diabetes, nerve problems (because of the increased incidence of peripheral neuropathy with Isoniazid), kidney, HIV, any allergy, who are taking other medications, during pregnancy and breastfeeding. Avoid alcohol consumption. Avoid consuming tyramine containing food items such as cheese, red wine, beer, certain meats and sausages, liver, sour cream. Otherwise it may cause high blood pressure. Monitor liver function and blood sugar level regularly while taking this medication.

Symptoms of Overdosage

ISONIAZID over-dosage can result in: Vomit, Dizziness, Drowsiness, Slurred Speech, Eyes Blurred Vision, Hallucinations, Difficulty Breathing, Increased Thirst, Frequent Urination, Fruity Odor On Breath

Common Side-Effects

ETHAMBUTOL HYDROCHLORIDE : Indigestion, Color Blindness, Joint Pain, Head Headache, Dizziness, Nausea, Vomit, Abdomen Pain, Loss Of Appetite, Ankles Joint Pain, Knees Joint Pain, Chills
PYRAZINAMIDE : Nausea, Vomit, Loss Of Appetite, Arms Joint Pain
RIFAMPICIN : Head Headache, Dizziness, Vomit, Nausea, Fever, Chills
ISONIAZID : Dark Colored (brown) Urine, Loss Of Appetite, Nausea, Fatigue (tiredness), Hands Numbness, Eyes Yellow Eyes

Serious Side-Effects

ETHAMBUTOL HYDROCHLORIDE : Jaundice, Vision Problems, Acute Liver Failure, Eyes Change In Vision, Difficulty Breathing, Cough, Fever, Confusion, Hallucinations, Hands Tingling, Chest Pain, Gums Bleeding, Easy Bleeding, Decreased Urination, Upper Abdomen Pain, Eyes Yellow Eyes, Dark Colored (brown) Urine, Body Pain, Face Swelling, Eyes Burn, Throat Soreness
PYRAZINAMIDE : Fatigue (tiredness), Weakness (generalized), Abdomen Pain, Eyes Yellow Eyes, Dark Colored (brown) Urine

Rare Side-Effects

ETHAMBUTOL HYDROCHLORIDE : Skin Rash, Eyes Pain, Eyes Blurred Vision, Hands Burn
PYRAZINAMIDE : Skin Rash, Face Swelling, Body Itching, Difficulty Breathing
ISONIAZID : Skin Rash, Eyes Blurred Vision, Eyes Pain, Seizures (uncontrollable Jerking Of Limbs), Throat Soreness, Mood Swings

Disease Interactions

ISONIAZID can interfere with: Acute Liver Failure, Alcoholism, Malnutrition, Diabetes Mellitus, Peripheral Neuropathy, Acute Renal Failure

Technical Classification

ETHAMBUTOL HYDROCHLORIDE is categorized as: MISCELLANEOUS ANTITUBERCULOSIS AGENTS / ANTITUBERCULOSIS AGENTS / ANTI-INFECTIVES
PYRAZINAMIDE is categorized as: MISCELLANEOUS ANTITUBERCULOSIS AGENTS / ANTITUBERCULOSIS AGENTS / ANTI-INFECTIVES
RIFAMPICIN is categorized as: MISCELLANEOUS ANTIBIOTICS / ANTI-INFECTIVES
ISONIAZID is categorized as: HYDRAZIDE DERIVATIVES / ANTITUBERCULOSIS AGENTS / ANTI-INFECTIVES

Available Alternatives for 4-D PLUS KIT

What are the commonly available Substitutes?

4-D PLUS KITINR 16.48 for 1 KITETHAMBUTOL HYDROCHLORIDE 1100 MG, PYRAZINAMIDE 800 MG, RIFAMPICIN 600 MG, ISONIAZID 300 MG

What are the other drugs with similar Ingredients?

R-CINEX-EZ FC-TABINR 37.34 for 6 TABLETSPYRAZINAMIDE 750 MG, ETHAMBUTOL HYDROCHLORIDE 400 MG, RIFAMPICIN 225 MG, ISONIAZID 150 MG