COMBIGAN EYE-DPS

Overview

COMBIGAN EYE-DPS is a Schedule H drug.

COMBIGAN EYE-DPS is composed of: BRIMONIDINE (0.2 %W/V), TIMOLOL (0.5 %W/V)

Brimonidine belongs to a group of drugs called alpha adrenergic agonists. The eye drops work by decreasing the amount of fluid produced in the eyes. The gel form works by reducing the amount of blood flow to the facial area. Decreasing blood flow may reduce overall redness associated with rosacea. Brimonidine ophthalmic (for the eyes) is used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye).


Timolol is a beta-blocker that affects the heart and circulation Timolol is sometimes given with other blood pressure medication.It works by relaxing blood vessels and slowing heart rate. It works by blocking the action of certain natural chemicals in your body such as epinephrine on the heart and blood vessels.

Usage

BRIMONIDINE is generally used to treat: Glaucoma, Rosacea, Open-Angle Glaucoma

TIMOLOL is generally used to treat: Hypertension, Heart Attack, Migraine, Glaucoma, Ocular Hypertension
TIMOLOL can address symptoms like: Head Headache, Eyes Blurred Vision, Dizziness, Chest Pain, Difficulty Breathing, Abdomen Pain, Chest Burn, Rapid Heart Rate (pulse)

Frequently Asked Questions

Q: Is it safe on my liver?
A: Check with your Doctor first

Q: Is it safe on my kidney?
A: Check with your Doctor first

Q: Can I take it with alcohol?
A: Not Safe

Q: Is it safe for children?
A: Ask your doctor

Q: Can it be taken during pregnancy?
A: Not enough studies to prove Risk – Ask your Doctor

Precautions for COMBIGAN EYE-DPS and its Constituents

• Before using this medication, tell your doctor or pharmacist your medical history, especially of blood circulation disorders (cerebral or coronary insufficiency), heart disease, depression, Raynaud’s disease, low blood pressure upon standing (orthostatic hypotension), a certain immune system disorder (Sjogren’s syndrome), a certain skin/connective tissue disease (scleroderma).
• Avoid certain triggers that may worsen rosacea such as wind, hot beverages, spicy foods, alcohol, and extreme cold. Discuss with your doctor.
• Sun exposure can worsen rosacea. Limit exposure to the sun by wearing a wide-brimmed hat and using a sunscreen that is SPF 15 or greater.
• Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
• During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
• It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

• You should not use timolol if you have asthma or other breathing disorders, or a serious heart condition such as heart failure or COPD.
• You should not use timolol if you are allergic to it.
• Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.
• Do not use timolol in larger or smaller amounts or for longer than recommended.Your blood pressure will need to be checked often.
• You should not stop using timolol suddenly. Stopping suddenly may make your condition worse.
• If you are taking timolol to prevent migraine headaches: It may take 6 to 8 weeks of daily use before timolol is fully effective.
• Do not take extra medicine to make up the missed dose.It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.
• It may affect blood sugar level, monitor sugar level regularly.

Symptoms of Overdosage

TIMOLOL over-dosage can result in: Wheezing, Difficulty Breathing, Fainting, Slow Heart Rate (pulse), Dizziness, Eyes Blurred Vision, Ringing In Ears, Head Headache, Hearing Loss, Nervousness, Ear Pounding, Body Excessive Sweating

Common Side-Effects

BRIMONIDINE : Itchy Skin, Depression, Skin Rash, Eyes Pain, Eyes Blindness, Eyes Bleeding, Confusion, Dizziness, Fainting, Irregular Heartbeat, Eyes Watery Eyes, Vomit, Fatigue (tiredness), Body Excessive Sweating, Sneezing, Runny Nose, Nausea, Depressed Mood
TIMOLOL : Itchy Skin, Dizziness, Nausea, Abdomen Upset Stomach, Fatigue (tiredness), Lightheadedness, Irregular Heartbeat, Labored Breathing, Chest Discomfort, Eyes Redness, Dry Mouth

Serious Side-Effects

BRIMONIDINE : Eyes Blurred Vision, Eyes Burning Sensation, Eyes Double Vision (without One Eye Covered), Head Headache
TIMOLOL : Depression, Heart Failure, Difficulty Breathing, Chest Pain, Shortness Of Breath, Rapid Heart Rate (pulse), Ankles Swelling, Feet Swelling, Weight Gain, Mood Swings

Rare Side-Effects

TIMOLOL : Indigestion, Heartburn, Noisy Breathing, Hands Swelling, Belching, Unable To Obtain Or Maintain Erection, Hallucinations, Nausea, Spinning Sensation, Abdomen Discomfort, Abdomen Pain

Food Interactions

 Separate the administration times of timolol and multivitamin with minerals by at least 2 hours.

Disease Interactions

TIMOLOL can interfere with: COPD, Asthma, Heart Block, Sinus Node Disease, Hypotension, Congestive Heart Disease, Diabetes Mellitus, Allergy, Ischemic Heart Disease, PAD (Peripheral Artery Disease), Acute Liver Failure, Acute Renal Failure, Glaucoma, Hyperlipidemia, Hyperthyroidism, Myoneural Disorders, Pheochromocytoma, Psoriasis, Heart Arrhythmias, Prinzmetal’s Variant Angina

Technical Classification

BRIMONIDINE is categorized as: OPHTHALMIC GLAUCOMA AGENTS / OPHTHALMIC PREPARATIONS / TOPICAL AGENTS
TIMOLOL is categorized as: NON-CARDIOSELECTIVE BETA BLOCKERS / BETA-ADRENERGIC BLOCKING AGENTS / CARDIOVASCULAR AGENTS

Available Alternatives for COMBIGAN EYE-DPS

What are the commonly available Substitutes?

BETABRIM 0.5% W/V/0.2% W/V EYE DPS	INR 260.5 for 5 ML EYE DROP	BRIMONIDINE 0.2 %W/V, TIMOLOL 0.5 %W/V
BIDIN T EYE DPS	INR 124.5 for 5 ML EYE DROP	TIMOLOL 0.5 %W/V, BRIMONIDINE 0.2 %W/V
BRIMOCOM 0.5% W/V/0.2% W/V EYE DPS	INR 240.5 for 5 ML EYE DROP	TIMOLOL 0.5 %W/V, BRIMONIDINE 0.2 %W/V
BRITIBLU 0.5% W/V/0.2% W/V EYE DPS	INR 130.5 for 5 ML EYE DROP	BRIMONIDINE 0.2 %W/V, TIMOLOL 0.5 %W/V
CIBRIM T EYE DPS	INR 95 for 5 ML EYE DROP	BRIMONIDINE 0.2 %W/V, TIMOLOL 0.5 %W/V
COMBIGAN 0.5%/0.2% EYE DPS	INR 385.53 for 5 ML EYE DROP	TIMOLOL 0.5 %W/V, BRIMONIDINE 0.2 %W/V
COMBIGAN EYE-DPS	INR 385.53 for 5 ML EYE DROP	BRIMONIDINE 0.2 %W/V, TIMOLOL 0.5 %W/V
IOTIM B 0.5% W/V/0.2% W/V EYE DPS	INR 290 for 5 ML EYE DROP	TIMOLOL 0.5 %W/V, BRIMONIDINE 0.2 %W/V
RIMOFLO T EYE DPS	INR 239 for 5 ML EYE DROP	TIMOLOL 0.5 %W/V, BRIMONIDINE 0.2 %W/V

What are the other drugs with similar Ingredients?

ABPRESS EYE DPS	INR 186 for 5 ML EYE DROP	TIMOLOL 0.5 %, BRIMONIDINE 0.15 %
AKUDIN T 0.15%/0.5% EYE DPS	INR 199 for 5 ML EYE DROP	TIMOLOL 0.15 %, BRIMONIDINE 0.5 %
ALBRIM LST 5MG/2MG EYE DPS	INR 262.25 for 5 ML EYE DROP	TIMOLOL 5.0 MG, BRIMONIDINE 2.0 MG
ALFAPREST T EYE DPS	INR 165 for 5 ML EYE DROP	TIMOLOL , BRIMONIDINE
APBIDIN TM EYE DPS	INR 155.97 for 5 ML EYE DROP	BRIMONIDINE , TIMOLOL 0.2 %
BIDIN LS TM EYE DPS	INR 171 for 5 ML EYE DROP	TIMOLOL 0.5 %W/V, BRIMONIDINE 0.1 %W/V
BRIMOCHEK T 0.5%/0.15% EYE DPS	INR 258.4 for 5 ML EYE DROP	BRIMONIDINE 0.15 %, TIMOLOL 0.5 %
BRIMOFINET 5MG/1.5MG EYE DPS	INR 150 for 5 ML EYE DROP	TIMOLOL 5.0 MG, BRIMONIDINE 1.5 MG
BRIMOLOL 5MG/1.5MG EYE DPS	INR 295 for 5 ML EYE DROP	TIMOLOL 5.0 MG, BRIMONIDINE 1.5 MG
BRIMOPRESS T EYE DPS	INR 246.91 for 5 ML EYE DROP	TIMOLOL 0.2 %, BRIMONIDINE
BRIMOTIM 0.5%/0.2% EYE DPS	INR 176 for 5 ML EYE DROP	TIMOLOL 0.5 %, BRIMONIDINE 0.2 %
BRIMOTUS EYE DPS	INR 161.9 for 5 ML EYE DROP	BRIMONIDINE , TIMOLOL
BRIOPT 0.5%/0.2% EYE DPS	INR 259 for 5 ML EYE DROP	BRIMONIDINE 0.2 %, TIMOLOL 0.5 %
GLOBRIM T 5MG/2MG EYE DPS	INR 128.75 for 5 ML EYE DROP	TIMOLOL 5.0 MG, BRIMONIDINE 2.0 MG
GLUBRIM EYE DPS	INR 146.25 for 5 ML EYE DROP	TIMOLOL , BRIMONIDINE