ENTACOM PLUS TAB

Overview

ENTACOM PLUS TAB is a Schedule H drug.

ENTACOM PLUS TAB is composed of: ENTACAPONE (200 MG), LEVODOPA (50 MG), CARBIDOPA (12.5 MG)

When used with carbidopa and levodopa (Atamet, Parcopa, Sinemet), entacapone increases levels of levodopa in the body. Entacapone is used together with carbidopa and levodopa to treat "wearing-off" symptoms of Parkinson’s disease, such as stiffness, tremors, muscle spasms, and poor muscle control.

Levodopa is used alone or in combination with carbidopa to treat Parkinson’s disease, sometimes referred to as shaking palsy. Some patients require the combination of medicine, while others benefit from levodopa alone.Levodopa works by being converted to dopamine, a chemical messenger that is needed to control the movement through transmission of signals in the brain.Levodopa is also used to relieve bone pain caused by cancer and to control pain caused by shingles.

Carbidopa is used with another medicine called levodopa to treat the symptoms of Parkinson’s disease (stiffness, tremors, spasms, poor muscle control). Symptoms of Parkinson’s disease may be caused by low levels of a chemical called dopamine (DOE pa meen) in the brain. Levodopa is converted to dopamine in the brain. Carbidopa helps prevent the breakdown of levodopa before it can reach the brain and take effect. Carbidopa is only used in combination with levodopa. Carbidopa has no effect when used alone. Carbidopa is also used with levodopa to treat muscle symptoms similar to Parkinson’s disease that are caused by certain drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), and others.
Carbidopa is always given with levodopa. It works by preventing levodopa from being broken down before it reaches the brain. This allows for a lower dose of levodopa, which causes less nausea and vomiting.

Usage

ENTACAPONE is generally used to treat: Parkinson’s Disease
ENTACAPONE can address symptoms like: Arms Stiffness, Body Muscle Cramps Or Spasms (painful)

LEVODOPA is generally used to treat: Parkinson’s Disease
LEVODOPA can address symptoms like: Muscle Stiffness, Slurred Speech, Difficulty Swallowing, Body Loss Of Movement, Loss Of Balance, Hands Shaking, Difficulty Standing, Body Difficulty Walking, Loss Of Coordination, Difficulty Staying Awake During Day, Restless Or Irritability, Dizziness, Confusion, Fatigue (tiredness), Slow Thinking, Anxiety, Urine Leaking (incontinence), Drooling, Jaws Stiffness

CARBIDOPA is generally used to treat: Parkinson’s Disease
CARBIDOPA can address symptoms like: Body Loss Of Movement, Muscle Stiffness

Frequently Asked Questions

Q: Is it safe on my liver?
A: Not Safe

Q: Is it safe on my kidney?
A: Not Safe

Q: Can I take it with alcohol?
A: Not Safe

Q: Is it safe for children?
A: Ask your doctor

Q: Can it be taken during pregnancy?
A: Not enough studies to prove Risk – Ask your Doctor

Q: Is it safe to take for someone breastfeeding?
A: Not Safe

How Do I Take It?

ENTACOM PLUS TAB is generally taken With Food.

Precautions for ENTACOM PLUS TAB and its Constituents

It may cause dizziness, lightheadedness, or fainting; do not drive a car or operate machinery, while taking this medication. Avoid alcohol consumption. It may lead to an increase in involuntary movements. Caution needed during pregnancy and breastfeeding.

• If you are taking carbidopa with levodopa, do not take iron salts within 2 hours before or a diet that is high in protein.
• Avoid vitamin products that contain vitamin B6 (pyridoxine). This vitamin may reduce the effectiveness of levodopa.Do not use levodopa, if you are allergic to levodopa or any other ingredient.
• Do not use levodopa, if you have narrow-angle glaucoma; if you are suffering from malignant melanoma, skin cancer or you have any unusual moles; severe mental disorder.
• Do not take levodopa, if you have a history of fits (convulsions); heart problems or blood pressure problems; asthma or other lung problems; liver or kidney problems; blood or hormone (endocrine) problems; depression or any other psychiatric disorder; ulcer in your gut or have vomited blood or stomach or intestinal bleeding.
• If you are undergoing any tests for urine glucose or urine ketones, levodopa may cause the results of some tests to be wrong.
• Levodopa may cause drowsiness, dizziness, light-headedness or sudden sleep. Do not drive or use machinery while using it.
• Do not take alcohol along with levodopa.
• Avoid excess dosage.

• Take carbidopa with food along with levodopa.
• Do not take iron salts (eg. ferrous sulfate), within 2 hours before or 2 hours after taking carbidopa. If you have been taking levodopa alone, do not start taking carbidopa until at least 12 hours after your final dose of levodopa.
• Do not use carbidopa if you are allergic to carbidopa or any other ingredient.
• Do not use carbidopa if you have narrow-angle glaucoma.
• Avoid using carbidopa in pregnant, planning to become pregnant, or breast-feeding.
•  Do not take carbidopa, if you have undiagnosed skin growths, skin cancer, or a history of skin cancer; heart problems; ulcers; seizures ; blood pressure problems; asthma or lung problems; liver or kidney problems; blood or hormone problems.
• Avoid taking carbidopa if you suffer from mental or mood problems, or suicidal thoughts or attempts. Take precaution if you have a diet that is high in protein as it may decrease your body’s ability to absorb carbidopa.
•  Take precaution if you are undergoing any tests for urine glucose or urine ketones, carbidopa may cause the results of some tests to be wrong.
•   Consult your doctor if you have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine.
•   In some cases after using carbidopa sweat, urine, or saliva appears dark in color, such as red, brown, or black. It is not a harmful side effect, but it may cause staining of clothes or bed sheets.
• Carbidopa may cause drowsiness, dizziness, light-headedness or sudden sleep. Do not drive or use machinery while using it.
•  Do not take alcohol along with carbidopa.
• Follow all directions on your prescription label.
• Do not take this medicine in larger or smaller amounts or for longer than recommended.
• If you already take levodopa but have never taken carbidopa before, start taking both medicines at least 12 hours after you last took levodopa by itself.
• Use carbidopa with levodopa regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
• Do not stop using carbidopa suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Symptoms of Overdosage

ENTACAPONE over-dosage can result in: Agitation, Fainting, Drowsiness, Confusion
CARBIDOPA over-dosage can result in: Difficulty Breathing

Common Side-Effects

ENTACAPONE : Body Loss Of Movement, Hyperactive Behavior, Hallucinations, Cough, Hoarse Voice, Fever, Chills, Lower Back Pain, Difficulty Urinating
LEVODOPA : Depression, Diarrhoea, Nausea, Vomit, Fatigue (tiredness), Eyes Blurred Vision, Difficulty Urinating, Difficulty Opening Mouth, Eyes Enlarged (dilated) Pupils, Dizziness, Hot Flashes, Irregular Heartbeat, Weight Gain, Eyes Double Vision (without One Eye Covered), Mood Swings, Eyes Blinking Eyes, Loss Of Appetite, Abdomen Pain, Dry Mouth, Increased Passing Gas, Constipation, Head Headache, Hiccups, Difficulty Sleeping, Body Excessive Sweating
CARBIDOPA : Dizziness, Essential Tremor, Neuroleptic Malignant Syndrome, Panic Attack, Tachycardia, Hallucination, Constipation, Diarrhoea, Mood Swings, Difficulty Sleeping, Confusion, Fever, Drowsiness, Nausea, Body Excessive Sweating, Irregular Heartbeat, Vomit, Dry Mouth, Head Headache, Loose Motion, Frightening Dreams

Serious Side-Effects

LEVODOPA : Night Terrors, Orthostatic Hypotension, Agitation, Anxiety, Slow Thinking, Confusion, Difficulty Swallowing, Grinding Teeth, Fainting, Excessive Mouth Watering, Body Discomfort, Hallucinations
CARBIDOPA : Hives, Skin Rash, Itchy Skin, Depression, Irregular Heartbeat, Manic Depression, Bipolar, Anxiety, Breathlessness, Chest Pain, Bloody Or Red Colored Stools, Fever, Throat Soreness, Eyes Pain, Grinding Teeth, Fatigue (tiredness), Legs Swelling, Arms Swelling, Eyes Eye Irritation, Wheezing, Pale Skin, Bloody Or Red Colored Vomit

Rare Side-Effects

ENTACAPONE : Confusion, Body Muscle Cramps Or Spasms (painful), Body Pain, Shortness Of Breath, Body Stiffness, Fatigue (tiredness), Weakness (generalized)
LEVODOPA : Seizure, Blood Pressure, High, Black (tar) Colored Stools, Bloody Or Red Colored Stools, Chills, Legs Pain, Eyes Jerking Eye Movements, Feet Swelling, Throat Soreness, Face Swelling, Bloody Or Red Colored Vomit
CARBIDOPA : Neuroleptic Malignant Syndrome, Rapid Breathing, Face Swelling

Food Interactions

• You should avoid levodopa with multivitamins and multi minerals.
• Avoid products containing iron also.

Disease Interactions

CARBIDOPA can interfere with: Glaucoma, Hypotension, Psychosis, Depression

Technical Classification

ENTACAPONE is categorized as: DOPAMINERGIC ANTIPARKINSONISM AGENTS / ANTIPARKINSON AGENTS / CENTRAL NERVOUS SYSTEM AGENTS
LEVODOPA is categorized as: DOPAMINERGIC ANTIPARKINSONISM AGENTS / ANTIPARKINSON AGENTS / CENTRAL NERVOUS SYSTEM AGENTS
CARBIDOPA is categorized as: DOPAMINERGIC ANTIPARKINSONISM AGENTS / ANTIPARKINSON AGENTS / CENTRAL NERVOUS SYSTEM AGENTS

Available Alternatives for ENTACOM PLUS TAB

What are the commonly available Substitutes?

ELCAPON 50MG/12.5MG/200MG TAB	INR 53.63 for 10 TABLETS	ENTACAPONE 200.0 MG, LEVODOPA 50.0 MG, CARBIDOPA 12.5 MG
ENTACOM PLUS 50MG/12.5MG/200MG TAB	INR 63 for 10 TABLETS	ENTACAPONE 200.0 MG, LEVODOPA 50.0 MG, CARBIDOPA 12.5 MG
ENTACOM PLUS TAB	INR 63 for 10 TABLETS	ENTACAPONE 200 MG, LEVODOPA 50 MG, CARBIDOPA 12.5 MG
SYNCAPONE 50MG TAB	INR 71 for 10 TABLETS	ENTACAPONE 200.0 MG, LEVODOPA 50.0 MG, CARBIDOPA 12.5 MG
SYNCAPONE TAB	INR 49 for 10 TABLETS	ENTACAPONE 200 MG, LEVODOPA 50 MG, CARBIDOPA 12.5 MG

What are the other drugs with similar Ingredients?

ELCAPON 100MG/25MG/200MG TAB	INR 61.5 for 10 TABLETS	ENTACAPONE 200.0 MG, LEVODOPA 100.0 MG, CARBIDOPA 25.0 MG
ENTACOM PLUS 100MG/25MG/200MG TAB	INR 74 for 10 TABLETS	ENTACAPONE 200.0 MG, LEVODOPA 100.0 MG, CARBIDOPA 25.0 MG
ENTACOM PLUS 150MG/12.5MG/200MG TAB	INR 85 for 10 TABLETS	ENTACAPONE 200.0 MG, LEVODOPA 150.0 MG, CARBIDOPA 12.5 MG
SYNCAPONE 100MG TAB	INR 82 for 10 TABLETS	ENTACAPONE 200.0 MG, LEVODOPA 100.0 MG, CARBIDOPA 25.0 MG
SYNCAPONE 150MG TAB	INR 93.5 for 10 TABLETS	ENTACAPONE 200.0 MG, LEVODOPA 150.0 MG, CARBIDOPA 37.5 MG