MIGRANIL EC 100MG/1MG/250MG/10MG TAB

Overview

MIGRANIL EC 100MG/1MG/250MG/10MG TAB is a Schedule H drug.

MIGRANIL EC 100MG/1MG/250MG/10MG TAB is composed of: PARACETAMOL (250.0 MG), CAFFEINE (100.0 MG), BELLADONNA DRY EXTRACT (10.0 MG), ERGOTAMINE (1.0 MG)

Paracetamol is a pain reliever and a fever reducer. The exact mechanism of action of is not known. Paracetamol is used to treat many conditions such as a headache, muscle aches, arthritis, backache, toothaches, colds, and fevers. It relieves pain in mild arthritis but has no effect on the underlying inflammation and swelling of the joint.

Caffeine is a central nervous system stimulant. It works by stimulating the brain. Caffeine is found naturally in foods and beverages such as coffee, tea, colas, energy and chocolate. Botanical sources of caffeine include kola nuts, guarana, and yerba mate. Caffeine is also available in prescription and non-prescription medications. Caffeine is used to restore mental alertness or wakefulness during fatigue or drowsiness. Caffeine is also found in some headache and migraine medications, in certain dietary supplements used for weight loss, and in many popular energy drinks.


Ergotamine is in a group of drugs called ergot alkaloids.It works by narrowing the blood vessels around the brain. Ergotamine also affects blood flow patterns that are associated with certain types of headaches.Ergotamine is used to treat a migraine type headache.This medication will only treat a headache that has already begun. It will not prevent migraine headaches or reduce the number of attacks.Ergotamine should not be used to treat common tension headaches or any headache that seems to be different from your usual migraine headaches.Ergotamine is used in acute attack of migraine and Raynaud’s disease.Migraine headaches are thought to result from the dilatation of blood vessels in the head. Ergotamine works by constricting (narrowing) these blood vessels, thereby relieving the migraine headaches.

Usage

PARACETAMOL is generally used to treat: Arthritis
PARACETAMOL can address symptoms like: Head Headache, Back Pain, Cold, Fever

CAFFEINE is generally used to treat: Migraine
CAFFEINE can address symptoms like: Weakness (generalized), Fatigue (tiredness), Drowsiness, Head Headache


ERGOTAMINE is generally used to treat: Migraine, Raynaud’s Disease Phenomenon, Cluster Headache, Postpartum Hemorrage
ERGOTAMINE can address symptoms like: Head Headache

Frequently Asked Questions

Q: Is it safe on my liver?
A: Not Safe

Q: Is it safe on my kidney?
A: Not Safe

Q: Can I take it with alcohol?
A: Not Safe

Q: Is it safe for children?
A: Not Advised for age < 1month

Q: Can it be taken during pregnancy?
A: Dangerous – Studies indicate Human-Fetal Risk

Q: Is it safe to take for someone breastfeeding?
A: Not Safe

Precautions for MIGRANIL EC 100MG/1MG/250MG/10MG TAB and its Constituents

Caution should be exercised in patients with history of asthma, bleeding problems, growths in the nose, heart, kidney or liver disease, liver inflammation, high blood pressure, chickenpox, anxiety, trouble in sleeping, ulcers, stomach problems, stroke, Kawasaki syndrome, any allergy, who are taking other medications, during pregnancy and breastfeeding. Avoid alcohol consumption. It should not be used in children with infections such as flu, chickenpox or viral infections. Avoid large amount of caffeinated beverages while taking this medication. It may reduce platelet counts; avoid injury or bruising.
While taking this medication avoid drinking excess amount of caffeine containing drinks.  Though caffeine may increase alertness, it can cause dizziness. Hence avoid doing anything that requires concentration and can cause disability or death in case of an accident, e.g. driving a car or operating machinery. It is not to be used as a substitute for sleep. Caution should be exercised in patients with history of heart disease, kidney disease, liver disease, stomach problems (peptic ulcer), seizures, during pregnancy and breast feeding.

• Do not take ergotamine and consult your doctor:
• If you are allergic to it or to any other content in the medicine.
• If you have uncontrolled high blood pressure or suffer from heart, kidney or liver problems.
• If you are pregnant or breast-feeding a baby.If you are a smoker.
• Ergotamine can cause drowsiness and anxiety (trembling, sweating) therefore, caution has to be taken before operating an automobile or machinery or engaging in activities requiring mental alertness and coordination.
• Using certain medications together with ergotamine can cause even greater decreases in blood flow than ergotamine used alone, which can lead to dangerous side effects.
• Do not take ergotamine if you are also using any of the following medications:conivaptan (Vaprisol), imatinib (Gleevec), isoniazid (for treating tuberculosis), or nefazodone (an antidepressant);diclofenac (Arthrotec, Cataflam, Voltaren, Flector Patch, Solareze);clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek); clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), or voriconazole (Vfend); heart or blood pressure medication such as diltiazem (Cardizem, Dilacor, Tiazac), nicardipine (Cardene), quinidine (Quin-G), or verapamil (Calan, Covera, Isoptin, Verelan); orHIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase, Fortovase), or ritonavir (Norvir).

Symptoms of Overdosage

PARACETAMOL over-dosage can result in: Loss Of Appetite, Nausea, Vomit, Abdomen Pain, Weakness (generalized), Upper Abdomen Pain, Dark Colored (brown) Urine, Eyes Yellow Eyes
CAFFEINE over-dosage can result in: Anxiety, Confusion, Frequent Urination, Irregular Heartbeat, Arms Muscle Twitching (painless), Ringing In Ears, Seizures (uncontrollable Jerking Of Limbs), Abdomen Pain, Difficulty Sleeping
ERGOTAMINE over-dosage can result in: Nausea, Vomit, Chest Pain, Fingers Tingling, Weakness (generalized)

Common Side-Effects

CAFFEINE : Enterocolitis, Confusion, Dizziness, Restless Or Irritability, Nervousness, Depressed Mood, Fatigue (tiredness), Head Headache, Lightheadedness, Seizures (uncontrollable Jerking Of Limbs), Irregular Heartbeat, Vomit, Nausea, Frequent Urination, Difficulty Breathing
ERGOTAMINE : Muscle Pain, Dizziness, Spinning Sensation, Nausea, Vomit, Weakness (generalized), Restless Or Irritability, Difficulty Sleeping

Serious Side-Effects

ERGOTAMINE : Blood Pressure, High, Anxiety, Seizure, Sudden Numbness Or Weakness On One Side Of Body, Head Headache, Confusion, Slurred Speech, Eyes Blurred Vision, Loss Of Balance, Irregular Heartbeat, Legs Weakness, Abdomen Pain, Decreased Urination, Fingers Blue Colored Skin

Rare Side-Effects

PARACETAMOL : Skin Rash, Dizziness, Difficulty Breathing, Face Swelling, Body Itching
ERGOTAMINE : Acute Liver Failure, Acute Kidney Failure

Food Interactions

• Nicotine may increase the effects of ergotamine in narrowing the blood vessels and decreasing blood flow.
• A severe decrease in blood flow to the brain and other parts of the body can lead to dangerous side effects.
• Grapefruit juice may increase the blood levels and effects of certain medications such as ergotamine.
• You may want to limit your consumption of grapefruit and grapefruit juice during treatment with ergotamine

Technical Classification

PARACETAMOL is categorized as: MISCELLANEOUS ANALGESICS / ANALGESICS / CENTRAL NERVOUS SYSTEM AGENTS
CAFFEINE is categorized as: CNS STIMULANTS / CENTRAL NERVOUS SYSTEM AGENTS
ERGOTAMINE is categorized as: ANTIMIGRAINE AGENTS / ANALGESICS / CENTRAL NERVOUS SYSTEM AGENTS

Available Alternatives for MIGRANIL EC 100MG/1MG/250MG/10MG TAB

What are the commonly available Substitutes?

MIGRANIL EC 100MG/1MG/250MG/10MG TAB	INR 42.3 for 10 TABLETS	PARACETAMOL 250.0 MG, CAFFEINE 100.0 MG, BELLADONNA DRY EXTRACT 10.0 MG, ERGOTAMINE 1.0 MG
MIGRANIL TAB	INR 42.3 for 10 TABLETS	PARACETAMOL 250.0 MG, CAFFEINE 100.0 MG, BELLADONNA DRY EXTRACT 10.0 MG, ERGOTAMINE 1.0 MG