SYNDOPA PLUS 125MG TAB

Overview

SYNDOPA PLUS 125MG TAB is a Schedule H drug.

SYNDOPA PLUS 125MG TAB is composed of: LEVODOPA (100 MG), CARBIDOPA (25 MG)

Levodopa is used alone or in combination with carbidopa to treat Parkinson’s disease, sometimes referred to as shaking palsy. Some patients require the combination of medicine, while others benefit from levodopa alone.Levodopa works by being converted to dopamine, a chemical messenger that is needed to control the movement through transmission of signals in the brain.Levodopa is also used to relieve bone pain caused by cancer and to control pain caused by shingles.

Carbidopa is used with another medicine called levodopa to treat the symptoms of Parkinson’s disease (stiffness, tremors, spasms, poor muscle control). Symptoms of Parkinson’s disease may be caused by low levels of a chemical called dopamine (DOE pa meen) in the brain. Levodopa is converted to dopamine in the brain. Carbidopa helps prevent the breakdown of levodopa before it can reach the brain and take effect. Carbidopa is only used in combination with levodopa. Carbidopa has no effect when used alone. Carbidopa is also used with levodopa to treat muscle symptoms similar to Parkinson’s disease that are caused by certain drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), and others.
Carbidopa is always given with levodopa. It works by preventing levodopa from being broken down before it reaches the brain. This allows for a lower dose of levodopa, which causes less nausea and vomiting.

Usage

LEVODOPA is generally used to treat: Parkinson’s Disease
LEVODOPA can address symptoms like: Muscle Stiffness, Slurred Speech, Difficulty Swallowing, Body Loss Of Movement, Loss Of Balance, Hands Shaking, Difficulty Standing, Body Difficulty Walking, Loss Of Coordination, Difficulty Staying Awake During Day, Restless Or Irritability, Dizziness, Confusion, Fatigue (tiredness), Slow Thinking, Anxiety, Urine Leaking (incontinence), Drooling, Jaws Stiffness

CARBIDOPA is generally used to treat: Parkinson’s Disease
CARBIDOPA can address symptoms like: Body Loss Of Movement, Muscle Stiffness

Frequently Asked Questions

Q: Is it safe on my liver?
A: Not Safe

Q: Is it safe on my kidney?
A: Not Safe

Q: Can I take it with alcohol?
A: Not Safe

Q: Is it safe for children?
A: Ask your doctor

Q: Can it be taken during pregnancy?
A: Not enough studies to prove Risk – Ask your Doctor

How Do I Take It?

SYNDOPA PLUS 125MG TAB is generally taken With Food.

Precautions for SYNDOPA PLUS 125MG TAB and its Constituents

• If you are taking carbidopa with levodopa, do not take iron salts within 2 hours before or a diet that is high in protein.
• Avoid vitamin products that contain vitamin B6 (pyridoxine). This vitamin may reduce the effectiveness of levodopa.Do not use levodopa, if you are allergic to levodopa or any other ingredient.
• Do not use levodopa, if you have narrow-angle glaucoma; if you are suffering from malignant melanoma, skin cancer or you have any unusual moles; severe mental disorder.
• Do not take levodopa, if you have a history of fits (convulsions); heart problems or blood pressure problems; asthma or other lung problems; liver or kidney problems; blood or hormone (endocrine) problems; depression or any other psychiatric disorder; ulcer in your gut or have vomited blood or stomach or intestinal bleeding.
• If you are undergoing any tests for urine glucose or urine ketones, levodopa may cause the results of some tests to be wrong.
• Levodopa may cause drowsiness, dizziness, light-headedness or sudden sleep. Do not drive or use machinery while using it.
• Do not take alcohol along with levodopa.
• Avoid excess dosage.

• Take carbidopa with food along with levodopa.
• Do not take iron salts (eg. ferrous sulfate), within 2 hours before or 2 hours after taking carbidopa. If you have been taking levodopa alone, do not start taking carbidopa until at least 12 hours after your final dose of levodopa.
• Do not use carbidopa if you are allergic to carbidopa or any other ingredient.
• Do not use carbidopa if you have narrow-angle glaucoma.
• Avoid using carbidopa in pregnant, planning to become pregnant, or breast-feeding.
•  Do not take carbidopa, if you have undiagnosed skin growths, skin cancer, or a history of skin cancer; heart problems; ulcers; seizures ; blood pressure problems; asthma or lung problems; liver or kidney problems; blood or hormone problems.
• Avoid taking carbidopa if you suffer from mental or mood problems, or suicidal thoughts or attempts. Take precaution if you have a diet that is high in protein as it may decrease your body’s ability to absorb carbidopa.
•  Take precaution if you are undergoing any tests for urine glucose or urine ketones, carbidopa may cause the results of some tests to be wrong.
•   Consult your doctor if you have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine.
•   In some cases after using carbidopa sweat, urine, or saliva appears dark in color, such as red, brown, or black. It is not a harmful side effect, but it may cause staining of clothes or bed sheets.
• Carbidopa may cause drowsiness, dizziness, light-headedness or sudden sleep. Do not drive or use machinery while using it.
•  Do not take alcohol along with carbidopa.
• Follow all directions on your prescription label.
• Do not take this medicine in larger or smaller amounts or for longer than recommended.
• If you already take levodopa but have never taken carbidopa before, start taking both medicines at least 12 hours after you last took levodopa by itself.
• Use carbidopa with levodopa regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
• Do not stop using carbidopa suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Symptoms of Overdosage

CARBIDOPA over-dosage can result in: Difficulty Breathing

Common Side-Effects

LEVODOPA : Depression, Diarrhoea, Nausea, Vomit, Fatigue (tiredness), Eyes Blurred Vision, Difficulty Urinating, Difficulty Opening Mouth, Eyes Enlarged (dilated) Pupils, Dizziness, Hot Flashes, Irregular Heartbeat, Weight Gain, Eyes Double Vision (without One Eye Covered), Mood Swings, Eyes Blinking Eyes, Loss Of Appetite, Abdomen Pain, Dry Mouth, Increased Passing Gas, Constipation, Head Headache, Hiccups, Difficulty Sleeping, Body Excessive Sweating
CARBIDOPA : Dizziness, Essential Tremor, Neuroleptic Malignant Syndrome, Panic Attack, Tachycardia, Hallucination, Constipation, Diarrhoea, Mood Swings, Difficulty Sleeping, Confusion, Fever, Drowsiness, Nausea, Body Excessive Sweating, Irregular Heartbeat, Vomit, Dry Mouth, Head Headache, Loose Motion, Frightening Dreams

Serious Side-Effects

LEVODOPA : Night Terrors, Orthostatic Hypotension, Agitation, Anxiety, Slow Thinking, Confusion, Difficulty Swallowing, Grinding Teeth, Fainting, Excessive Mouth Watering, Body Discomfort, Hallucinations
CARBIDOPA : Hives, Skin Rash, Itchy Skin, Depression, Irregular Heartbeat, Manic Depression, Bipolar, Anxiety, Breathlessness, Chest Pain, Bloody Or Red Colored Stools, Fever, Throat Soreness, Eyes Pain, Grinding Teeth, Fatigue (tiredness), Legs Swelling, Arms Swelling, Eyes Eye Irritation, Wheezing, Pale Skin, Bloody Or Red Colored Vomit

Rare Side-Effects

LEVODOPA : Seizure, Blood Pressure, High, Black (tar) Colored Stools, Bloody Or Red Colored Stools, Chills, Legs Pain, Eyes Jerking Eye Movements, Feet Swelling, Throat Soreness, Face Swelling, Bloody Or Red Colored Vomit
CARBIDOPA : Neuroleptic Malignant Syndrome, Rapid Breathing, Face Swelling

Food Interactions

• You should avoid levodopa with multivitamins and multi minerals.
• Avoid products containing iron also.

Disease Interactions

CARBIDOPA can interfere with: Glaucoma, Hypotension, Psychosis, Depression

Technical Classification

LEVODOPA is categorized as: DOPAMINERGIC ANTIPARKINSONISM AGENTS / ANTIPARKINSON AGENTS / CENTRAL NERVOUS SYSTEM AGENTS
CARBIDOPA is categorized as: DOPAMINERGIC ANTIPARKINSONISM AGENTS / ANTIPARKINSON AGENTS / CENTRAL NERVOUS SYSTEM AGENTS

Prescription Statistics

Following information is taken from treatment plans advised by our doctors. This is Only for informational purpose and you must seek doctor’s advice if you are not well.

How Frequently is it taken?

3 Times Daily	58%
Every 6hrs	12%
2 Times Daily (1-0-1)	7%
2 Times Daily	6%
Others	3%
Morning	3%
2 Times Daily (1-1-0)	2%

What was the Dosage Advised?

1/2tab	67%
1/2 tab	13%
1tab	11%

Directions with respect to food?

Before Food	89%
After Food	11%

How long was it prescribed?

28 Days	22%
90 Days	17%
30 Days	14%
60 Days	13%
7 Days	12%
14 Days	6%
45 Days	3%
5 Days	3%

What is the break-up across patient age-group?

Below 5yrs	1%
5 to 12yrs	1%
12 to 18yrs	1%
18 to 35yrs	1%
35 to 50yrs	2%
50 to 60yrs	11%
60 to 70yrs	30%
70yrs and above	53%

What is the gender-breakup across patients?

Females

32%

What kind of doctors prescribe this medicine?

Neurologist	93%
Physician	3%
Cardiologist	2%
Nephrologist	1%

Most common Medicines advised along-side?

PACITANE 2MG TAB	16%
RASALECT 1MG TAB	16%

Most common Diagnostic/Lab Tests advised along-side?

SERUM POTASSIUM (SEROLOGY)	11%
SERUM SODIUM (SEROLOGY)	11%

Available Alternatives for SYNDOPA PLUS 125MG TAB

What are the commonly available Substitutes?

SYNDOPA CR 125 TAB	INR 23.97 for 10 TABLETS	LEVODOPA 100.0 MG, CARBIDOPA 25.0 MG
SYNDOPA MD PLUS TAB	INR 24.64 for 10 TABLETS	LEVODOPA 100.0 MG, CARBIDOPA 25.0 MG
SYNDOPA PLUS 125MG TAB	INR 22.47 for 10 TABLETS	LEVODOPA 100 MG, CARBIDOPA 25 MG
TIDOMET PLUS TAB	INR 22.05 for 10 TABLETS	LEVODOPA 100 MG, CARBIDOPA 25 MG

What are the other drugs with similar Ingredients?

ELCAPON 100MG/25MG/200MG TAB	INR 61.5 for 10 TABLETS	ENTACAPONE 200.0 MG, LEVODOPA 100.0 MG, CARBIDOPA 25.0 MG
ELCAPON 50MG/12.5MG/200MG TAB	INR 53.63 for 10 TABLETS	ENTACAPONE 200.0 MG, LEVODOPA 50.0 MG, CARBIDOPA 12.5 MG
ENTACOM PLUS 100MG/25MG/200MG TAB	INR 74 for 10 TABLETS	ENTACAPONE 200.0 MG, LEVODOPA 100.0 MG, CARBIDOPA 25.0 MG
ENTACOM PLUS 150MG/12.5MG/200MG TAB	INR 85 for 10 TABLETS	ENTACAPONE 200.0 MG, LEVODOPA 150.0 MG, CARBIDOPA 12.5 MG
ENTACOM PLUS 50MG/12.5MG/200MG TAB	INR 63 for 10 TABLETS	ENTACAPONE 200.0 MG, LEVODOPA 50.0 MG, CARBIDOPA 12.5 MG
ENTACOM PLUS TAB	INR 63 for 10 TABLETS	ENTACAPONE 200 MG, LEVODOPA 50 MG, CARBIDOPA 12.5 MG
LCD 100MG/10MG TAB	INR 33 for 10 TABLETS	LEVODOPA 100.0 MG, CARBIDOPA 10.0 MG
LCD 200MG/75MG TAB	INR 25 for 10 TABLETS	LEVODOPA 200.0 MG, CARBIDOPA 75.0 MG
LEVOCOM TAB	INR 36.54 for 10 TABLETS	LEVODOPA 250.0 MG, CARBIDOPA
SYNCAPONE 100MG TAB	INR 82 for 10 TABLETS	ENTACAPONE 200.0 MG, LEVODOPA 100.0 MG, CARBIDOPA 25.0 MG
SYNCAPONE 150MG TAB	INR 93.5 for 10 TABLETS	ENTACAPONE 200.0 MG, LEVODOPA 150.0 MG, CARBIDOPA 37.5 MG
SYNCAPONE 50MG TAB	INR 71 for 10 TABLETS	ENTACAPONE 200.0 MG, LEVODOPA 50.0 MG, CARBIDOPA 12.5 MG
SYNCAPONE TAB	INR 49 for 10 TABLETS	ENTACAPONE 200 MG, LEVODOPA 50 MG, CARBIDOPA 12.5 MG
SYNDOPA 110 TAB	INR 15.52 for 10 TABLETS	LEVODOPA 100 MG, CARBIDOPA 10 MG
SYNDOPA 275 TAB	INR 40.81 for 10 TABLETS	LEVODOPA 250.0 MG, CARBIDOPA 25.0 MG
SYNDOPA CR 250 TAB	INR 56.06 for 10 TABLETS	LEVODOPA 200.0 MG, CARBIDOPA 50.0 MG
SYNDOPA FORTE TAB	INR 40.43 for 10 TABLETS	LEVODOPA NAN, CARBIDOPA NAN
SYNDOPA MD 110 TAB	INR 16.91 for 10 TABLETS	LEVODOPA 100.0 MG, CARBIDOPA 10.0 MG
SYNDOPA MD 275 TAB	INR 40.43 for 10 TABLETS	LEVODOPA 250.0 MG, CARBIDOPA 25.0 MG
TIDOMET FORTE TAB	INR 36.33 for 10 TABLETS	LEVODOPA 250 MG, CARBIDOPA 25 MG
TIDOMET LS TAB	INR 15.12 for 10 TABLETS	LEVODOPA 100 MG, CARBIDOPA 10 MG
TIDOMET-CR TAB	INR 41.7 for 10 TABLETS	LEVODOPA 200 MG, CARBIDOPA 50 MG